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Search Results for " EGFR tyrosine kinase "

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カタログ番号	製品名	別名	ターゲット
T41099	EGFR Protein Tyrosine Kinase Substrate
	EGFR Protein Tyrosine Kinase Substrate is a EGFR protein tyrosine kinase substrate.
T9865	Almonertinib mesylate		EGFR
	Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer st...		EGFR
T4015	HG-14-10-04		ALK
	HG-14-10-04 is a potent and specific ALK inhibitor.		ALK
T3024	Avitinib	AC0010	EGFR , JAK , BTK
	Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administrat...		EGFR , JAK , BTK
T39275	Befotertinib	D-0316,Befotertinib	EGFR
	Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.		EGFR
T6712	Tyrphostin AG 879	AG 879	Apoptosis , EGFR , Trk receptor , HER , PDGFR
	Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.		Apoptosis , EGFR , Trk receptor , HER , PDGFR
T4185	Lavendustin C	HDBA,NSC 666251	CaMK , EGFR , Tyrosinase , Src
	lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.		CaMK , EGFR , Tyrosinase , Src
T9304	(S)-Sunvozertinib	N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008	EGFR , HER
	(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.		EGFR , HER
T77746	Tyrosine kinase-IN-7		EGFR , Antiviral
	Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity in a variety of cancer cell lines. Tyrosine kinase-IN-7 has pote...		EGFR , Antiviral
T60108	PDGFR Tyrosine Kinase Inhibitor III	PDGF Receptor Tyrosine Kinase Inhibitor III	PDGFR
	PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC, respectively. PDGF...		PDGFR
T4326	AG 555	Tyrphostin B46,Tyrphostin AG 555	EGFR , Reverse Transcriptase
	AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.		EGFR , Reverse Transcriptase
T2307	Icotinib Hydrochloride	BPI-2009H	EGFR
	Icotinib Hydrochloride (BPI-2009H) is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineoplastic activity. Icotinib selectively inhibits the wild-type ...		EGFR
T2034	AG1557	AG-1557,AG 1557	EGFR , HER
	AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).		EGFR , HER
T21322	Mavelertinib	PF 06747775,PFE-X775,PF-06747775,PF-7775,PF 6747775,PF6747775	EGFR
	Mavelertinib (PF-06747775) is an orally available, selective and potent EGFR tyrosine kinase (EGFR TKI) inhibitor with inhibitory effects on T790M/L858R and T790M/Del, and can be used in the study of oncology and respira...		EGFR
T7649	Tyrphostin A1	AG9,Tyrphostin 1	EGFR , Interleukin
	Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .		EGFR , Interleukin
T14692	BMX-IN-1	BMX kinase inhibitor	BTK
	BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 ...		BTK
T7175	Alflutinib mesylate	AST2818 mesylate	EGFR
	Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.		EGFR
T4694	AG-1557 hydrochloride (189290-58-2(free base))		EGFR , HER
	AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).		EGFR , HER
T73334	Larotinib		EGFR , IRAK , Tyrosine Kinases , BTK
	Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.		EGFR , IRAK , Tyrosine Kinases , BTK
T19814	CP-380736	PF 00520893,CP380736,PF00520893,CP 380736,PF-00520893	EGFR
	CP-380736 (PF-00520893) is an epidermal growth factor receptor (EGFR) inhibitor. EGFR is a tyrosine kinase that activates MAPK, JNK, and Akt pathways, and is an important mediator of several types of cancer.		EGFR
T35914	Epitinib succinate	HMPL-813 succinate	EGFR
	Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.		EGFR
T3569	SU5214	SU 5214	VEGFR , Tyrosinase
	SU5214 is a modulator of tyrosine kinase signal transduction.		VEGFR , Tyrosinase
T11158	EGFR-IN-11		EGFR
	EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.		EGFR
T2325	Neratinib	HKI-272	EGFR , HER
	Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.		EGFR , HER
T8976	PD-089828		EGFR , FGFR , PDGFR , Src
	PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 ...		EGFR , FGFR , PDGFR , Src
TQ0166	Tesevatinib	KD-019,XL-647,EXEL-7647	EGFR , VEGFR , FLT , Ephrin Receptor
	Tesevatinib (XL-647) is an orally available, multi-target tyrosine kinase inhibitor (IC50s: 0.3, 16, 1.5, 8.7, and 1.4 nM for EGFR, ErbB2, KDR, Flt4, and EphB4).		EGFR , VEGFR , FLT , Ephrin Receptor
T6217	LFM-A13		PLK , JAK , BTK
	LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.		PLK , JAK , BTK
T79888	EGFR-IN-87		EGFR
	EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750, EGFR_L858R/T790M, and EGFR_WT, respectively, in A431 cells. It ...		EGFR
T11213	Epertinib hydrochloride	S-22611 hydrochloride	EGFR , HER
	Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity. Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s ...		EGFR , HER
T21622	Tyrphostin A25	AG-82,Tyrphostin AG 82,RG-50875	EGFR , GPR
	Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.3 μM for GPR35.		EGFR , GPR
T8327	ONO-7475		Trk receptor , TAM Receptor
	ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase		Trk receptor , TAM Receptor
T6136	Canertinib	PD-183805,CI-1033	EGFR
	Canertinib (CI-1033) is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo. Canertinib treatment significantly affects tumour metabolism, proliferation and hyp...		EGFR
T9754	BLU-945	BLU945,BLU 945	EGFR
	BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, effective against EGFR with L858R and/or exon 19 deletion mutations, T790M, and C797...		EGFR
T10534	BI-4020		EGFR
			EGFR
TQ0271	Falnidamol	BIBX 1382	EGFR
	Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine k...		EGFR
T1773	Afatinib Dimaleate	BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate	EGFR , HER , Autophagy
	Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act...		EGFR , HER , Autophagy
T10870L	CP-547632		VEGFR , FGFR , PDGFR , BTK
			VEGFR , FGFR , PDGFR , BTK
T0078L	Lapatinib ditosylate monohydrate	Lapatinib ditosylate monohydrate,Lapatinib ditoluenesulfonate monohydrate,Lapatinib tosilate hydrate,Lapatinib tosilate,Tykerb,Tyverb	EGFR , Ferroptosis , Autophagy
	Lapatinib ditosylate (Lapatinib tosilate) monohydrate is a tyrosine kinase receptor inhibitor used in the therapy of advanced breast cancer and other solid tumors. Lapatinib ditosylate monohydrate therapy is associated w...		EGFR , Ferroptosis , Autophagy
T2064	Semaxinib	SU5416	VEGFR
	Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR than PDGFRβ, lack of activity against InsR, EGFR, and FGFR. Semaxanib reversibly inhibits ATP binding to the...		VEGFR
T16549	PKI-166		VEGFR
	PKI-166 is an oral inhibitor of EGF-R tyrosine kinase (IC50:0.7 nM) that is both effective and selective. PKI-166 can effectively inhibit the growth and metastasis of various human cancer cells including pancreatic cance...		VEGFR
T22827	GW 583340 dihydrochloride		Others
	dual EGFR/ErbB2 tyrosine kinase inhibitor		Others
T34916	Transtinib
	Transtinib is an effective and irreversible EGFR tyrosine kinase inhibitor (EGFR-TKI) that is active against L858R/T790M mutated NSCLC cell lines and xenografts.
T71902	CHEMBL94431
	CHEMBL94431 is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase.
T36643	PKI-166 hydrochloride
	Potent EGFR-kinase inhibitor (IC50 = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and o...
T61441	NSC381467
	NSC381467, a potent and orally active inhibitor of the EGFR tyrosine kinase (EGFR-TK), exhibits robust antiproliferative activity, making it a promising candidate for cancer research [1].
T70317	BIBU-1361 dihydrochloride
	BIBU-1361 dihydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that blocks downstream EGFR signaling events such as MAPKK/MAPK activation.
T11385	Gefitinib N-oxide		Others
	Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.		Others
T11213L	Epertinib	S-22611	EGFR , HER
	Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor activity.		EGFR , HER
T70227	BPIQ-I	PD 159121
	BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.
T11229	Erlotinib-d6	OSI-774 D6,NSC 718781 D6,CP-358774 D6	Others
	Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR. Erlotinib D6 is a deuterium labeled Erlotinib .		Others

Compounds

EGFR Protein Tyrosine Kinase Substrate

T41099

Synonym:

Target:

Almonertinib mesylate

Target: EGFR, JAK, BTK

Befotertinib

T39275

Synonym: D-0316,Befotertinib

Target: Apoptosis, EGFR, Trk receptor, HER, PDGFR

lavendustin C

T4185

Synonym: HDBA,NSC 666251

Target: CaMK, EGFR, Tyrosinase, Src

(S)-Sunvozertinib

T9304

Synonym: N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008

Target: EGFR, HER

Tyrosine kinase-IN-7

T77746

Synonym:

Target: EGFR, Antiviral

PDGFR Tyrosine Kinase Inhibitor III

T60108

Synonym: PDGF Receptor Tyrosine Kinase Inhibitor III

Target: PDGFR

AG 555

T4326

Synonym: Tyrphostin B46,Tyrphostin AG 555

Target: EGFR, Reverse Transcriptase

Icotinib Hydrochloride

Synonym: AG-1557,AG 1557

Target: EGFR, HER

Mavelertinib

T21322

Synonym: PF 06747775,PFE-X775,PF-06747775,PF-7775,PF 6747775,PF6747775

Target: EGFR

Tyrphostin A1

T7649

Synonym: AG9,Tyrphostin 1

Target: EGFR, Interleukin

BMX-IN-1

T14692

Synonym: BMX kinase inhibitor

Target: BTK

Alflutinib mesylate

T7175

Synonym: AST2818 mesylate

Target: EGFR

AG-1557 hydrochloride (189290-58-2(free base))

Target: EGFR, IRAK, Tyrosine Kinases, BTK

CP-380736

T19814

Synonym: PF 00520893,CP380736,PF00520893,CP 380736,PF-00520893

Target: EGFR

Epitinib succinate

T35914

Synonym: HMPL-813 succinate

Target: VEGFR, Tyrosinase

Target: EGFR, FGFR, PDGFR, Src

Tesevatinib

TQ0166

Synonym: KD-019,XL-647,EXEL-7647

Target: EGFR, VEGFR, FLT, Ephrin Receptor

LFM-A13

T6217

Synonym:

Target: PLK, JAK, BTK

Epertinib hydrochloride

T11213

Synonym: S-22611 hydrochloride

Target: EGFR, HER

Tyrphostin A25

T21622

Synonym: AG-82,Tyrphostin AG 82,RG-50875

Target: Trk receptor, TAM Receptor

Canertinib

T6136

Synonym: PD-183805,CI-1033

Target: EGFR

BLU-945

T9754

Synonym: BLU945,BLU 945

Synonym: BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate

Target: EGFR, HER, Autophagy

CP-547632

T10870L

Synonym:

Target: VEGFR, FGFR, PDGFR, BTK

Lapatinib ditosylate monohydrate

T0078L

Synonym: Lapatinib ditosylate monohydrate,Lapatinib ditoluenesulfonate monohydrate,Lapatinib tosilate hydrate,Lapatinib tosilate,Tykerb,Tyverb

Target: EGFR, Ferroptosis, Autophagy

GW 583340 dihydrochloride

PKI-166 hydrochloride

BIBU-1361 dihydrochloride

Synonym: OSI-774 D6,NSC 718781 D6,CP-358774 D6

Target: Others

カタログ番号	製品名	別名	ターゲット
T1181	Gefitinib	ZD1839	EGFR , Tyrosine Kinases , Autophagy
	Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell...		EGFR , Tyrosine Kinases , Autophagy
T4183	Lavendustin A	RG-14355,NSC 678027	EGFR , Tyrosinase
	lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.		EGFR , Tyrosinase
T6427	Butein	2’,3,4,4’-tetrahydroxy Chalcone	Apoptosis , EGFR , Others , PDE , Autophagy
	Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.		Apoptosis , EGFR , Others , PDE , Autophagy
TN2504	1,5-Dihydroxyxanthone		EGFR , AChR
	1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have anticholinesterase activity on acetylcholinesterase (AChE) and...		EGFR , AChR

天然物製品

Gefitinib

T1181

Synonym: ZD1839

Target: EGFR, Tyrosine Kinases, Autophagy

lavendustin A

T4183

Synonym: RG-14355,NSC 678027

Target: EGFR, Tyrosinase

Butein

T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone

Target: Apoptosis, EGFR, Others, PDE, Autophagy

1,5-Dihydroxyxanthone

TN2504

Synonym:

Target: EGFR, AChR

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00648	EGFR vIII Protein, Human, Recombinant (His)	Human	HEK293 Cells
	EGFR vIII Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 61-75 Kda and the accession number is NP_001333870.
TMPJ-00647	EGFR vIII Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	EGFR vIII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is NP_001333870.
TMPJ-00646	EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 60-90 KDa and the accession number is NP_001333870.
TMPY-04484	ACK1 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	ACK1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non-receptor tyrosine kinase that is expressed in diverse cell types. This downstream effector of CDC42 mediates CDC42-dependent cell mig...
TMPK-00870	AREG Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine...

EGFR vIII Protein, Human, Recombinant (His)

TMPJ-00648

Species: Human

Expression System: HEK293 Cells

EGFR vIII Protein, Human, Recombinant (hFc)

TMPJ-00647

Species: Human

Expression System: HEK293 Cells

EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated

TMPJ-00646

Species: Human

Expression System: HEK293 Cells

ACK1 Protein, Human, Recombinant (GST)

TMPY-04484

Species: Human

Expression System: Baculovirus Insect Cells

AREG Protein, Mouse, Recombinant (hFc)

TMPK-00870

Species: Mouse

Expression System: HEK293 Cells

カタログ番号	製品名
L9410	Covalent Inhibitor Library		1920 compounds
	A unique collection of 1920 covalent Inhibitors and other molecules with common warheads like chloroacetyl，2-Chloropropionyl，Acryloyl，sulfonyl fluoride, alkyne，acrylamide, ketocarbonyl，disulfide bond, etc.

ライブラリー

Covalent Inhibitor Library

L9410

Compounds: 1920